Daily Disposable Senofilcon A Contact Lenses Improve Comfort, Dryness Symptoms

Inserting contact lens into the eye
Close-up of a man inserting a contact lens into his eye.
Alleviating dry eye symptoms and increasing comfort is crucial for successful outcomes in contact lens practice.

Refitting symptomatic contact lens wearers with daily disposable senofilcon A lenses may improve overall comfort and reduce symptoms of dryness, irrespective of prior habitual lens modality or material, according to research published in Contact Lens and Anterior Eye.

Researchers conducted a retrospective meta-analysis of 3 clinical trials in which they evaluated comfort and dryness in symptomatic patients who wore contact lenses. The team used Contact Lens User Experience (CLUE) comfort scores and the Contact Lens Dry Eye Questionnaire 8 (CLDEQ-8) to analyze patient comfort levels before and after refitting them to daily disposable senofilcon A contact lenses. 

Investigators used data from 107 patients (mean age, 30.8±9.03 years; 72.9% women) and stratified them according to habitual lens modality (daily disposable or daily wear reusable) and lens material (silicone hydrogel or hydrogel). 

The investigators reported that mean CLUE comfort and CLDEQ-8 scores were similar across all 3 studies at baseline and 2-week follow-up visits. The combined analysis revealed a mean baseline CLUE comfort score of 32.0 ± 2.9 and a mean baseline CLDEQ-8 score of 22.5 ± 0.8. Both the CLUE and CLDEQ-8 scores improved at  2-week follow-up after refitting (56.8 ± 3.3 and 11.9 ± 0.9, respectively). 

The team noted that overall mean CLUE comfort score improved by 24.8 points (95% CI, 18.5-31.1; P <.0001) and significantly increased between baseline and 2-week follow-up among all patient groups (P <.0001 for all), regardless of prior habitual lens modality or material. The CLUE comfort score showed clinically meaningful (≥5-point increase) improvement in 75.7% of patients after 2 weeks of wear.

The researchers also found that the overall mean CLDEQ-8 score improved by 10.6 points (95% CI, -10.9 to 6.0; P <.0001), indicating a decrease in dryness and discomfort symptoms. The CLDEQ-8 score showed clinically meaningful (≥3-point reduction) improvement in 82.2% of patients, and 57.0% of patients became asymptomatic (CLDEQ-8 score ≤11 points) after 2 weeks of bilateral wear.

“Symptoms of dryness and discomfort are reported to affect half of all soft contact lens wearers, which is a substantially greater proportion than that reported for non-contact lens wearers,” according to the investigators. They remind clinicians that “[working] to identify ways of alleviating these symptoms remains essential to contact lens practice.”

Limitations of the study included the retrospective design, lack of randomization to control groups, and failure to account for patient compliance regarding the use of their habitual lenses.

Disclosure: This research was supported by Johnson & Johnson Vision. Study authors also declared affiliation with biotech, pharmaceutical, and/or clinical research organizations. Please see the original reference for a full list of disclosures.


Bishop MJ, Sun C-k, Coles-Brennan C, Gallois-Bernos A. Evaluation of daily disposable senofilcon A contact lenses in a symptomatic population. Published online January 29, 2022. Cont Lens Ant Eye. doi:10.1016/j.clae.2022.101574