Indications for: NEXICLON XR
Individualize. Initially 0.17mg once daily at bedtime; may titrate by 0.09mg once daily in weekly increments if needed until desired response. Usual range: 0.17–0.52mg/day. Elderly: may benefit from a lower initial dose. ESRD on maintenance dialysis: initially 0.09mg/day and up-titrate slowly to minimize adverse events; monitor closely.
NEXICLON XR Warnings/Precautions:
Avoid abrupt cessation. Reduce dose gradually over 2–4 days to avoid withdrawal symptoms. Severe coronary insufficiency, conduction disturbances, recent MI, cerebrovascular disease, or chronic renal failure; monitor closely and up-titrate slowly. May be administered up to 28 hours prior to surgery and resumed the following day. If local contact sensitization or allergic reaction occurs from patch, using tabs may cause generalized rash or an allergic reaction. Renal impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.
NEXICLON XR Classification:
Central alpha-2 agonist.
NEXICLON XR Interactions:
May increase sedative effect with concomitant use of alcohol, barbiturates, or other sedating drugs. Antagonized by tricyclic antidepressants. Monitor heart rate in patients receiving agents known to affect sinus node function or AV nodal conduction (eg, digitalis, calcium channel blockers, β-blockers).
Dry mouth, drowsiness, dizziness, constipation, sedation.
Generic Drug Availability: