ADHD Treatments

ADHD TREATMENTS
Generic	Brand		Form	Strength	Max Dose	Administration
amphetamine	Adzenys ER	CII	ext-rel oral susp	1.25mg/mL	6-12yrs: 18.8mg (15mL) daily 13–17yrs: 12.5mg (10mL) daily	• Give once daily in the AM • May increase by 3.1mg (2.5mL) or 6.3mg (5mL) at weekly intervals
	Adzenys XR-ODT	CII	ext-rel orally disintegrating tabs	3.1mg, 6.3mg, 9.4mg, 12.5mg, 15.7mg, 18.8mg	6–12yrs: 18.8mg/day 13–17yrs: 12.5mg/day	• Give once daily in the AM • May increase by 3.1mg or 6.3mg at weekly intervals
	Dyanavel XR	CII	ext-rel oral susp	2.5mg/mL	≥6yrs: max 20mg/day	• Give once daily in the AM • May increase by 2.5–10mg/day every 4–7 days
amphetamine sulfate	Evekeo	CII	tabs	5mg, 10mg	3–5yrs: initially 2.5mg daily, may increase by 2.5mg/day at weekly intervals ≥6yrs: max 40mg/day	• Avoid late evening doses • Give first dose upon awakening and additional doses at 4−6hr intervals
amphetamine sulfate	Evekeo ODT	CII	tabs	5mg, 10mg, 15mg, 20mg	6-17yrs: 40mg/day	• Give first dose once or twice daily and additional dose after 4–6hrs • Titrate in increments of 5mg at weekly intervals
atomoxetine HCl	Strattera	Rx	caps	10mg, 18mg, 25mg, 40mg, 60mg, 80mg, 100mg	≥6yrs: 1.4mg/kg or 100mg/ day (which– ever is less)	• Swallow whole • Give once daily in the AM or in 2 divided doses (in AM + the late afternoon/ early PM) • May discontinue without tapering dose
clonidine HCl	Kapvay	Rx	ext-rel tabs	0.1mg	0.2mg twice daily	• Swallow whole • Titrate by response • Withdraw gradually by 0.1mg/day at 3−7 day intervals
dextro– amphetamine sulfate	—	CII	scored tabs	5mg, 10mg	usually 40mg/day in 2−3 divided doses	• Give in the AM and then 1−2 more doses 4−6hrs apart
	Dexedrine Spansule	CII	sust-rel caps	5mg, 10mg, 15mg	usually 40mg/day	• Avoid late evening doses
	Zenzedi	CII	tabs	2.5mg, 5mg, 7.5mg, 10mg, 15mg, 20mg, 30mg	≥3yrs: usually 40mg/day in 2–3 divided doses	• Give first dose upon awakening and then 1–2 more doses 4–6hrs apart • Avoid late evening doses
dexmethyl– phenidate HCl	Focalin	CII	tabs	2.5mg, 5mg, 10mg	≥6yrs: 20mg/day	• Give twice daily at least 4hrs apart • Single isomer methylphenidate product (use 1/2 of racemic methylphenidate dose initially)
dexmethyl– phenidate HCl	Focalin XR	CII	ext-rel caps	5mg, 10mg, 15mg, 20mg, 25mg, 30mg, 35mg, 40mg	6–17yrs: 30mg/day ≥18yrs: 40mg/day	• Give once daily in the AM • May sprinkle contents on applesauce and swallow without chewing beads
guanfacine	Intuniv	Rx	ext-rel tabs	1mg, 2mg, 3mg, 4mg	6–12yrs: 4mg/day 13–17yrs: 7mg/day	• Swallow whole with water, milk, or other liquid • Do not give with high‑fat meals • Withdraw gradually by 1mg every 3−7days
lisdexam– fetamine dimesylate	Vyvanse	CII	caps, chew tabs	10mg, 20mg, 30mg, 40mg, 50mg, 60mg, 70mg (caps only)	≥6yrs: 70mg/day	• Give once daily in the AM. Do not subdivide a single dose. • Caps: swallow whole or may open and mix/dissolve contents in yogurt, water, or orange juice; take immediately • Chew tabs: chew thoroughly before swallowing
metham– phetamine HCl	Desoxyn	CII	tabs	5mg	≥6yrs: usually 20−25mg daily in two divided doses	• Give once or twice daily 30min before meals • May increase at weekly intervals
methylphen– idate	Cotempla XR-ODT	CII	ext-rel orally disintegrating tabs	8.6mg, 17.3mg, 25.9mg	6–17yrs: 51.8mg/day	• Give once daily in the AM • Place on tongue and allow to disintegrate • May titrate in increments of 8.6–17.3mg weekly
methylphen– idate	Daytrana	CII	trans– dermal patches	10mg, 15mg, 20mg, 30mg	—	• Apply patch to hip 2hrs before desired effect, remove 9hrs after application; may remove earlier if shorter duration of effect or late day side effect appears • May titrate dose at 1wk intervals
methylphen– idate HCl	—	CII	tabs	5mg	60mg/day in divided doses	• Give preferably 30−45min before meals
			ext-rel tabs	10mg, 20mg
			scored tabs	10mg, 20mg
			chew tabs	2.5mg, 5mg, 10mg	60mg/day in divided doses	• Give before breakfast and lunch
	Adhansia XR	CII	ext-rel caps	25mg 35mg, 45mg*, 55mg, 70mg, 85mg	Children: 85mg/day Adults: 100mg/day	• Give once daily in the AM • May titrate by 10–15mg at intervals of ≥5 days • May sprinkle contents on applesauce/yogurt and swallow immediately without chewing beads
	Aptensio XR	CII	ext-rel caps	10mg, 15mg, 20mg, 30mg, 40mg, 50mg, 60mg	≥6yrs: 60mg/day	• Give once daily in the AM • May titrate in increments of 10mg/day weekly • May sprinkle contents on applesauce and swallow without chewing beads
	Concerta	CII	ext-rel tabs (with immediate-release outer coating)	18mg, 27mg, 36mg, 54mg	6−12yrs: 54mg/day 13−17yrs: 72mg/day or 2mg/kg/day (whichever is less) ≥18yrs: 72mg/day	• Give once daily in the AM
	Jornay PM	CII	ext-rel caps	20mg, 40mg, 60mg, 80mg, 100mg	≥6yrs: 100mg/day	• Give once daily in the PM (between 6:30–9:30) • May titrate in 20mg increments weekly • May sprinkle contents on applesauce and swallow without chewing beads
	Metadate CD	CII	ext-rel caps (containing immediate and ext‑rel beads)	10mg, 20mg, 30mg, 40mg, 50mg, 60mg	60mg/day	• Give once daily in the AM before breakfast • May sprinkle contents on applesauce and swallow without chewing beads
	Methylin Oral Solution	CII	oral soln	5mg/ 5mL, 10mg/ 5mL	60mg/day in divided doses	• Give preferably 30−45min before meals
	Quillichew ER	CII	ext-rel chew tabs	20mg, 30mg, 40mg	60mg/day	• Give once daily in the AM • May titrate in increments of 10mg, 15mg, or 20mg
	Quillivant XR	CII	ext-rel oral susp	25mg/ 5mL	60mg/day	• Give once daily in the AM • Shake bottle vigorously for ≥10sec before use
	Ritalin	CII	tabs	5mg	≥6yrs: 60mg/day	• Give before breakfast and lunch
	Ritalin	CII	scored tabs	10mg, 20mg		• Give before breakfast and lunch
	Ritalin LA	CII	ext-rel caps (half as immediate-release, half as e‑c delayed-release beads)	10mg, 20mg, 30mg, 40mg	≥6yrs: 60mg/day	• Give once daily in the AM • May sprinkle contents on applesauce and swallow without chewing beads
mixed dextro– amphetamine/ amphetamine salts	—	CII	double-scored tabs	5mg, 7.5mg, 10mg, 12.5mg, 15mg, 20mg, 30mg	usually 40mg/day in 2−3 divided doses	• Give in AM and 4−6hrs apart
	Adderall XR	CII	ext-rel caps	5mg, 10mg, 15mg, 20mg, 25mg, 30mg	30mg/day	• Give once daily in the AM • May sprinkle contents on applesauce and swallow without chewing beads
	Mydayis	CII	ext-rel caps	12.5mg, 25mg, 37.5mg, 50mg	13–17yrs: 25mg/day 18–55yrs: 50mg/day	• Give once daily in the AM • May increase by 12.5mg at weekly intervals • May sprinkle contents on applesauce and swallow without chewing beads
NOTES
*Contains tartrazine Not an inclusive list of medications, official indications, or dosing information. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Use lowest effective dose. Avoid late evening doses. Re‑evaluate periodically; improvement may be sustained when the drug is either temporarily or permanently discontinued. If paradoxical aggravation of symptoms or other adverse effects occur, the dose should be reduced or discontinued. (Rev. 4/2020)

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