Antiepileptic Drug Indications

Antiepileptic Drug Indications

Partial Generalized
Generic Brand Form Simple Complex Absence Myoclonic Tonic-clonic Atonic Mixed Status Epilepticus Lennox-Gastaut Others7
Adrenocorticotropic Hormone (Acth) Analogue
corticotrophin H.P. Acthar Gel gel for IM, SC inj
Alpha-2 Delta Ligand
pregabalin Lyrica CV caps, oral susp 1 1
perampanel Fycompa CIII tabs, oral susp 1
brivaracetam Briviact CV tabs, oral soln, IV inj
divalproex sodium Depakote del-rel tabs 1
Depakote ER ext-rel tabs 1
Depakote Sprinkle del-rel coated particles in caps 1
gabapentin Neurontin caps, tabs, oral soln 1 1
levetiracetam Keppra tabs, oral soln, IV inj 1 1
Keppra XR ext-rel tabs
Spritam tabs for oral susp 1 1 1 1
rufinamide Banzel tabs, oral susp 1
stiripentol Diacomit caps, oral susp
valproate sodium Depacon IV inj 2 2 1,2
valproic acid caps, syrup 1
vigabatrin Sabril tabs, pwd for oral soln 1,3
primidone Mysoline tabs
clobazam Onfi CIV tabs, oral soln 1
Sympazan CIV oral films 1
clonazepam CIV ODT 3
Klonopin CIV tabs 3
diazepam CIV IM, IV inj 1 1
oral soln 1 1 1 1 1,5 1 1 1
Diastat CIV rectal gel
Diazepam Intensol CIV oral soln 1 1 1 1 1,5 1 1 1
Valium CIV tabs 1 1 1 1 1,5 1 1 1
Valtoco CIV nasal spray
lorazepam Ativan CIV IM, IV inj
midazolam Nayzilam CIV nasal spray
cannabidiol Epidiolex CV oral soln
carbamazepine Carbatrol ext-rel caps
Equetro ext-rel caps
Tegretol tabs, chew tabs, oral susp
Tegretol XR ext-rel tabs
eslicarbazepine Aptiom tabs
oxcarbazepine Oxtellar XR ext-rel tabs
Trileptal tabs, oral susp
ethotoin Peganone tabs
fosphenytoin Cerebyx IV, IM inj 2 2 6
phenytoin IV inj 6
Dilantin ext-rel caps, oral susp
Dilantin Infatabs chew tabs
Phenytek ext-rel caps
lamotrigine Lamictal tabs, chew tabs, ODT 1,4 1,4 1 1
Lamictal XR  ext-rel tabs 1,4 1,4 1
lacosamide Vimpat CV tabs, oral soln, IV inj
ethosuximide Zarontin caps, syrup
methsuximide Celontin caps 3
topiramate Qudexy XR ext-rel caps 1
Topamax tabs 1
Topamax Sprinkle coated beads in caps 1
Trokendi XR ext-rel caps 1
zonisamide Zonegran caps 1 1

Key: AED = antiepileptic drug; del-rel = delayed-release; ext-rel = extended-release; ODT = orally-disintegrating tablets

1 Adjunct therapy only.

2 Temporary alternative to oral therapy.

3 Only if refractory to other therapy.

4 Conversion to monotherapy in adults with partial seizures who are on a single AED (see full labeling).

5 Also indicated for tonic seizure.

6 For generalized tonic-clonic status epilepticus.

7 Other indications include infantile spasms, Dravet syndrome, recurrent seizures, multiple seizure types, cluster seizures (episodes of increased seizure activity), neurosurgically-induced seizures; see full labeling.

Not an inclusive list of medications and/or official indications. Please see drug monograph at and/or contact company for full drug labeling.

(Rev. 4/2020)