Diabetes Treatments

DIABETES TREATMENTS
Generic	Brand	Strength	Form	Usual Maintenance Range	Usual Max Adult Dose
ALPHA-GLUCOSIDASE INHIBITOR
acarbose	Precose	25mg, 50mg, 100mg	tabs	50−100mg three times daily	≤60kg: 150mg/day in 3 divided doses >60kg: 300mg/day in 3 divided doses
miglitol	Glyset	25mg, 50mg, 100mg	tabs	50mg three times daily	300mg/day in 3 divided doses
AMYLIN ANALOGUE/AMYLINOMIMETIC
pramlintide	Symlin	1000mcg/mL	SC inj	Type 1: 30−60mcg Type 2: 60−120mcg	—
BIGUANIDE
metformin	Fortamet	500mg, 1000mg	ext‑rel tabs	—	2g/day
	Glucophage	500mg, 850mg, 1000mg	tabs	—	2.55g/day in 2–3 divided doses
	Glucophage XR	500mg, 750mg	ext‑rel tabs	—	2g/day in 1–2 divided doses
	Glumetza	500mg, 1000mg	ext‑rel tabs	—	2g/day
	Riomet	500mg/5mL	oral soln	—	2.55g/day (25.5mL) in 2–3 divided doses
	Riomet ER	500mg/5mL	ext-rel oral susp	—	2g/day (20mL) in 1–2 divided doses
BILE ACID SEQUESTRANT
colesevelam	Welchol	625mg	tabs	6 tabs once daily or 3 tabs twice daily	—
colesevelam	Welchol for Oral Suspension	3.75g	pwd pkts	One 3.75g pkt once daily	—
DIPEPTIDYL PEPTIDASE-4 INHIBITOR
alogliptin	Nesina	6.25mg, 12.5mg, 25mg	tabs	25mg once daily	—
linagliptin	Tradjenta	5mg	tabs	5mg once daily	—
saxagliptin	Onglyza	2.5mg, 5mg	tabs	2.5mg or 5mg once daily	—
sitagliptin	Januvia	25mg, 50mg, 100mg	tabs	100mg once daily	—
DIPEPTIDYL PEPTIDASE-4 INHIBITOR + BIGUANIDE
alogliptin/ metformin	Kazano	12.5mg/500mg, 12.5mg/1000mg	tabs	—	25mg/2000mg per day in divided doses
linagliptin/ metformin	Jentadueto	2.5mg/500mg, 2.5mg/850mg, 2.5mg/1000mg	tabs	—	2.5mg/1000mg twice daily
linagliptin/ metformin	Jentadueto XR	2.5mg/1000mg, 5mg/1000mg	ext-rel tabs	—	5mg/2000mg daily
saxagliptin/ metformin HCl ext‑rel	Kombiglyze XR	5mg/500mg, 5mg/1000mg, 2.5mg/1000mg	ext-rel tabs	—	5mg/2000mg per day
sitagliptin/ metformin	Janumet	50mg/500mg, 50mg/1000mg	tabs	—	100mg/2000mg per day
sitagliptin/ metformin	Janumet XR	50mg/500mg, 50mg/1000mg, 100mg/1000mg	ext‑rel tabs	—	100mg/2000mg per day
DIPEPTIDYL PEPTIDASE-4 INHIBITOR + THIAZOLIDINEDIONE
alogliptin/ pioglitazone	Oseni	12.5mg/15mg, 12.5mg/30mg, 12.5mg/45mg, 25mg/15mg, 25mg/30mg, 25mg/45mg	tabs	—	25mg/45mg daily
DOPAMINE RECEPTOR AGONIST
bromocriptine	Cycloset	0.8mg	tabs	1.6−4.8mg/ day	4.8mg/day

Generic	Brand	Strength	Form	Usual Maintenance Range	Usual Max Adult Dose
GLINIDE
nateglinide	Starlix	60mg, 120mg	tabs	120mg 1−30min before meals three times daily	360mg/day in 3 divided doses
repaglinide	Prandin	0.5mg, 1mg, 2mg	tabs	0.5−4mg within 30min of meals 2−4 times daily	16mg/day
GLINIDE + BIGUANIDE
repaglinide/ metformin	PrandiMet	1mg/500mg, 2mg/500mg	tabs	—	4mg/1000mg per meal or 10mg/2500mg per day
GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST
dulaglutide	Trulicity	0.75mg/0.5mL, 1.5mg/0.5mL	SC inj	0.75mg−1.5mg once weekly	1.5mg once weekly
exenatide	Byetta	250mcg/mL	SC inj	5−10mcg twice daily	10mcg twice daily
exenatide ext‑rel	Bydureon	2mg	SC inj	2mg once every 7 days	—
liraglutide	Victoza	6mg/mL	SC inj	1.2−1.8mg/ day	—
lixisenatide	Adlyxin	50mcg/mL, 100mcg/mL	SC inj	20mcg once daily	—
semaglutide	Ozempic	2mg/1.5mL	SC inj	0.5–1mg once weekly	1mg once weekly
semaglutide	Rybelsus	3mg, 7mg, 14mg	tabs	7−14mg once daily	14mg once daily
SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR
canagliflozin	Invokana	100mg, 300mg	tabs	100−300mg once daily	300mg once daily
dapagliflozin	Farxiga	5mg, 10mg	tabs	5−10mg once daily in AM	10mg once daily
empagliflozin	Jardiance	10mg, 25mg	tabs	10−25mg once daily	25mg once daily
ertugliflozin	Steglatro	5mg, 15mg	tabs	5−15mg once daily in AM	15mg once daily
SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR + BIGUANIDE
canagliflozin/ metformin HCl	Invokamet	50mg/500mg, 50mg/1000mg, 150mg/500mg, 150mg/1000mg	tabs	—	300mg/2000mg per day
canagliflozin/ metformin HCl	Invokamet XR	50mg/500mg, 50mg/1000mg, 150mg/500mg, 150mg/1000mg	ext-rel tabs
dapagliflozin/ metformin HCl ext‑rel	Xigduo XR	2.5mg/1000mg, 5mg/500mg, 5mg/1000mg, 10mg/500mg, 10mg/1000mg	ext-rel tabs	—	10mg/2000mg per day
empagliflozin/ metformin HCl	Synjardy	5mg/500mg, 12.5mg/500mg, 5mg/1000mg, 12.5mg/1000mg	tabs	—	25mg/2000mg per day
	Synjardy XR	5mg/1000mg, 10mg/1000mg, 12.5mg/1000mg, 25mg/1000mg	ext‑rel tabs
ertugliflozin/ metformin HCl	Segluromet	2.5mg/500mg, 2.5mg/1000mg, 7.5mg/500mg, 7.5mg/1000mg	tabs	—	15mg/2000mg per day
SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR + DIPEPTIDYL PEPTIDASE‑4 INHIBITOR
dapagliflozin/ saxagliptin	Qtern	5mg/5mg, 10mg/5mg	tabs	—	10mg/5mg once daily
empagliflozin/ linagliptin	Glyxambi	10mg/5mg, 25mg/5mg	tabs	—	25mg/5mg once daily
ertugliflozin/ sitagliptin	Steglujan	5mg/100mg, 15mg/100mg	tabs	—	15mg/100mg once daily
SULFONYLUREA
chlorpro– pamide 1st generation	—	100mg, 250mg	scored tabs	250−750mg once daily in AM	750mg/day
glimepiride	Amaryl	1mg, 2mg, 4mg	scored tabs	1−4mg once daily	8mg/day
glipizide 2nd generation	Glucotrol	5mg, 10mg	scored tabs	5−15mg once daily or 5−40mg in divided doses	15mg once daily or 40mg in divided doses
glipizide 2nd generation	Glucotrol XL	2.5mg, 5mg, 10mg	ext‑rel tabs	5−10mg once daily	20mg/day
glyburide 2nd generation	Diabeta	1.25mg, 2.5mg, 5mg	scored tabs	1.25−20mg in single or divided doses	20mg/day in single or divided doses
glyburide, micronized 2nd generation	Glynase PresTab	1.5mg, 3mg, 6mg	scored tabs	0.75−12mg in single or divided doses	12mg/day in divided doses
SULFONYLUREA + BIGUANIDE
glipizide/ metformin	—	2.5mg/250mg, 2.5mg/500mg, 5mg/500mg	tabs	—	20mg/2000mg per day in single or divided doses
glyburide/ metformin	—	2.5mg/500mg, 5mg/500mg	tabs	—	20mg/2000mg per day
THIAZOLIDINEDIONE
pioglitazone	Actos	15mg, 30mg, 45mg	tabs	15−45mg once daily	45mg once daily
rosiglitazone	Avandia	2mg, 4mg	tabs	4−8mg in single or 2 divided doses	8mg/day
THIAZOLIDINEDIONE + BIGUANIDE
pioglitazone/ metformin	ACTOplus met	15mg/500mg, 15mg/850mg	tabs	—	45mg/2550mg per day in divided doses
pioglitazone/ metformin	ACTOplus met XR	15mg/1000mg, 30mg/1000mg	ext‑rel tabs	—	45mg/2000mg per day
rosiglitazone/ metformin	—	1mg/500mg, 2mg/500mg, 4mg/500mg, 2mg/1000mg, 4mg/1000mg	tabs	—	8mg/2000mg per day in divided doses
THIAZOLIDINEDIONE + SULFONYLUREA
pioglitazone/ glimepiride	Duetact	30mg/2mg, 30mg/4mg	tabs	—	One 30mg/4mg tab once daily
rosiglitazone/ glimepiride	—	4mg/1mg, 4mg/2mg, 4mg/4mg, 8mg/2mg, 8mg/4mg	tabs	—	8mg/4mg per day
NOTES
Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. These products are intended for use as part of a total treatment regimen to maintain glycemic control that includes diet, regular exercise, blood glucose monitoring, and glycosylated hemoglobin monitoring. Patients should maintain regular caloric intake. Adjust dose based on clinical effect. Start at a low dose and gradually titrate upwards according to clinical effect (especially in the elderly, malnourished, debilitated, or those who have renal and/or hepatic dysfunction). (Rev. 6/2020)

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