Erectile Dysfunction Treatments

ERECTILE DYSFUNCTION TREATMENTS
Generic	Brand	Form	Strength	Onset	Duration of Action	Dosing Considerations
PDE-5 INHIBITORS
avanafil	Stendra	tabs	50mg, 100mg, 200mg	30− 45min (fasted state)	5hrs	• Initially 100mg 15min before sexual activity. • Max 200mg once daily. • Concomitant moderate CYP3A4 inhibitors: Max 50mg once every 24hrs. • Concomitant α-blockers: Initially 50mg.
sildenafil	Viagra	tabs	25mg, 50mg, 100mg	0.5−2hrs (1hr)	4hrs	• Usually 25−100mg 1hr before anticipated sexual activity. • >65yrs old: Initially 25mg. • Severe renal dysfunction (CrCl<30mL/min): Initially 25mg. • Hepatic impairment: Initially 25mg. • Ketoconazole, itraconazole, erythromycin, saquinavir: Initially 25mg. • Ritonavir: Max 25mg every 48hrs. • α-blockers: Initially 25mg.
tadalafil	Cialis	tabs	2.5mg, 5mg, 10mg, 20mg	0.5−6hrs (2hrs)	36hrs	Use as Needed: • Usually 5−20mg before anticipated sexual activity. • >65yrs old: No adjustment needed. • Moderate renal dysfunction (CrCl 30−50mL/min): Initially 5mg; max 10mg/48hrs. • Severe renal dysfunction (CrCl<30mL/min): Max 5mg/72hrs. • Mild or moderate hepatic impairment: Max 10mg daily; severe: Not recommended. • Ketoconazole, ritonavir: Max 10mg every 72hrs. • α-blockers: Lowest recommended dose.
tadalafil	Cialis	tabs	2.5mg, 5mg, 10mg, 20mg	0.5−6hrs (2hrs)	see literature	Once−Daily Use: • Initially 2.5mg (taken at same time each day); may increase to 5mg/day. • Severe renal dysfunction (CrCl<30mL/min): Not recommended. • Mild or moderate hepatic impairment: Use caution; severe: Not recommended. • Concomitant potent CYP3A4 inhibitors: Max 2.5mg. • For ED + BPH: 5mg taken at same time once daily without regard to timing of sexual activity.
varden– afil	Levitra	tabs	5mg, 10mg, 20mg	0.5−2hrs (1hr)	4hrs	• Initially 10mg 1hr before sexual activity; usual range: 5−20mg once daily as needed. • ≥65yrs old: Initially 5mg. • Moderate hepatic impairment: initially 5mg; max 10mg. • Concomitant ketoconazole or itraconazole 200mg/day, or erythromycin: max 5mg. Concomitant ketoconazole or itraconazole 400mg/day, clarithromycin, saquinavir, atazanavir or indinavir: max 2.5mg. Concomitant ritonavir: max 2.5mg/72hrs. • Concomitant α-blocker: initially 5mg/day.
varden– afil	Staxyn	orally disinte– grating tabs	10mg	0.75− 2.5hrs (1.5hr)	4−6hrs	• Take as needed approximately 60min before sexual activity; max: 10mg/day. • Not interchangeable with Levitra 10mg. • Do not take with water. Place on tongue to disintegrate. • Moderate to severe hepatic impairment or renal dialysis: Not recommended. • Concomitant α-blockers: use lower doses of vardenafil film-coated tabs as initial therapy.
PROSTAGLANDIN E1
alpros– tadil	Caverject	injection, intraca– vernous	20mcg, 40mcg	5−20min	1hr	• Usually 1.25−60mcg within 1hr before anticipated sexual activity. • Max 3 inj/wk with a 24‑hr period between each injection.
	Edex	injection, intraca– vernous	10mcg, 20mcg, 40mcg	7min	1hr	• Usually 1−40mcg within 1hr before anticipated sexual activity. • Max of 3 inj/wk with a 24‑hr period between each injection.
	Muse	supposi– tory, urethral	125mcg, 250mcg, 500mcg, 1000mcg	5−10min	0.5−1hr	• Initially 125−250mcg. • Max 2 systems/24hrs.
Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. (Rev. 1/2019)

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