Name: Ulcerative Colitis Treatments - Optometry Advisor
Published: 2021-09-29T13:05:00+00:00

ULCERATIVE COLITIS TREATMENTS
Generic	Brand	Strength	Form	Dose
AMINOSALICYLATE
balsalazide disodium	Colazal	750mg	caps	Adults: Treatment: 2.25g 3 times daily for 8wks; max 12wks. Children: <5yrs: not recommended. ≥5yrs: Treatment: 2.25g 3 times daily or 750mg 3 times daily; max 8wks.
mesalamine	Apriso	0.375g	ext-rel caps	≥18yrs: Maintenance: 1.5g once daily in the AM. <18yrs: Not recommended.
	Asacol HD	800mg	del-rel tabs	Adults: Treatment: 1600mg 3 times daily for 6wks. Children: Not recommended.
	Canasa	1g	supp	Adults: Treatment: 1g once daily at bedtime for 3−6wks. Retain supp in rectum for at least 1−3hrs. Children: Not established.
	Delzicol	400mg	del-rel caps	Adults: Treatment: 800mg 3 times daily for 6wks. Maintenance: 1.6g daily in 2−4 divided doses. Children: <5yrs: not established. ≥5yrs (17–32kg): 36−71mg/kg/day, max 1.2g/day; (33–53kg): 37−61mg/kg/day, max 2g/day; (54−90kg): 27−44mg/kg/day, max 2.4g/day; give in 2 divided doses for 6wks.
	Lialda	1.2g	del-rel tabs	≥18yrs: Remission induction: 2.4−4.8g once daily for up to 8wks. Maintenance: 2.4g once daily. <18yrs: Not established.
	Pentasa	250mg, 500mg	controlled-rel caps	Adults: 1g four times daily for up to 8wks. Children: Not established.
	Rowasa	4g/ 60mL	enema	Adults: Treatment: 4g (60mL) daily at bedtime for 3−6wks. Retain enema for 8hrs. Children: Not recommended.
olsalazine sodium	Dipentum	250mg	caps	Adults: Maintenance: 500mg twice daily with meals. Children: Not recommended.
sulfasalazine	Azulfidine	500mg	scored tabs	Adults: Treatment: Initially 1−2g daily, increase gradually to 3−4g daily in equally divided doses after meals until symptoms controlled. Maintenance: 2g daily; max 4g/day. Children: <6yrs: not established. ≥6yrs: Treatment: Initially 40−60mg/kg daily in 3−6 doses. Maintenance: 30mg/kg daily in 4 doses.
sulfasalazine	Azulfidine EN-tabs	500mg	e-c tabs
INTEGRIN RECEPTOR ANTAGONIST
vedolizumab	Entyvio	300mg/ vial	pwd for IV infusion after reconsti– tution	≥18yrs: Give by IV infusion over 30mins. 300mg at Weeks 0, 2, and 6, then every 8wks thereafter. Discontinue if no therapeutic benefit by Week 14. <18yrs: Not established.
JANUS KINASE INHIBITOR
tofacitinib	Xeljanz	5mg, 10mg	tabs	Adults: 10mg twice daily for 8wks, then 5mg twice daily. May continue 10mg twice daily dose for up to max 16wks if needed; limit to those with loss of response. Discontinue after 16wks if inadequate response with 10mg twice daily. Children: Not established.
STEROID
budesonide	Uceris	9mg	ext-rel tabs	Adults: Remission induction: 9mg once daily in the AM for up to 8wks. Children: Not established.
budesonide	Uceris Rectal Foam	2mg	emulsion	Adults: Apply 1 metered dose per rectum twice daily (AM & PM) for 2wks, then 1 metered dose once daily (PM) for 4wks. Children: Not established.
TNF-ALPHA BLOCKER
adalimumab	Humira	10mg/ 0.1mL, 10mg/ 0.2mL, 20mg/ 0.2mL, 20mg/ 0.4mL, 40mg/ 0.4mL, 40mg/ 0.8mL, 80mg/ 0.8mL	soln for SC inj	≥18yrs: Remission induction: 160mg (in 1 day or divided over 2 days) at Day 1, then 80mg at Day 15. Maintenance: At Day 29, start 40mg every other week. May continue aminosalicylates, corticosteroids, or immunomodulatory agents. Only continue if evidence of clinical remission by 8wks. <18yrs: Not recommended.
golimumab	Simponi	50mg/ 0.5mL, 100mg/ mL	soln for SC inj	Adults: Remission induction: Initially 200mg by SC inj at Week 0, followed by 100mg at Week 2. Maintenance: 100mg every 4wks. Rotate inj sites. <18yrs: Not established.
infliximab	Remicade	100mg/ vial	pwd for IV infusion after reconsti– tution and dilution	Adults: Give by IV infusion over at least 2hrs. 5mg/kg at Weeks 0, 2, 6, then every 8wks. Heart failure: max 5mg/kg. Children: <6yrs: Not established. ≥6yrs: Same as adult dose.
infliximab-abda	Renflexis
infliximab- dyyb	Inflectra
NOTES
Not an inclusive list of medications, indications, or dosing details. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. (Rev. 12/2019)

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