Highly Aspherical Lenslets Slow Myopia Progression in Children

Highly aspherical lenslets can slow myopia progression in children without producing a rebound effect after treatment discontinuation.

Highly aspherical lenslets (HAL) demonstrate better clinical efficacy in slowing axial length (AL) elongation and spherical equivalent (SE) progression in children compared with single vision (SV) lenses, according to research published in the American Journal of Ophthalmology. While switching from a HAL to SV myopia control modality allowed for more rapid myopia progression, it did not result in myopic rebound, according to the report. 

Researchers included 119 children with myopia and randomly assigned  them treatment with HAL (n=54; 31 boys; mean age, 11.2 years) or SV lenses (n=65; 34 boys; mean age, 10.9 years). After observing AL and SE changes for 6 months (stage 1), the participants’ treatment was switched for an additional 6 months (stage 2). All participants were treated with HAL following the crossover for another 6 months (stage 3), for a total study duration of 1.5 years. Investigators also monitored changes in SE and AL for participants who began the study with HAL and crossed over to SAL to determine whether a myopic rebound had taken place. 

Participants wearing HAL experienced less SE (stage 1: -0.21 vs -0.27 diopters [D]; P =.317; stage 2: -0.05 vs -0.32 D; P <.001) and AL progression (stage 1: 0.07 vs 0.14 mm, P =.004; stage 2: 0.04 vs 0.17 mm; P <.001) compared with individuals wearing SV lenses during both stages of the investigation. The changes in SE (HAL first group: -0.33 D; SV first group: -0.27 D; P =.208) and AL (HAL first group: 0.17 mm; SV first group: 0.13 mm; P =.092) experienced by individuals in both cohorts while wearing SV lenses were comparable, demonstrating that a myopic rebound did not occur during crossover. 

These results confirm the performance of HAL and also indicate no rebound when children switched from HAL to SV lenses.

“The progression rate with SV lenses in the [HAL-SV-HAL] group during stage 2 was similar to the progression rate in the {SV-HAL-HAL] group during stage 1. These results confirm the performance of HAL and also indicate no rebound when children switched from HAL to SV lenses,” according to the researchers.

Study limitations include a short duration and potential confounding due to lifestyle changes brought about by the COVID-19 pandemic. 

Disclosure: This research was supported by Essilor International, Brien Holden Vision Institute and Hai Yen Eye Care. Multiple study authors declared affiliations with biotech, pharmaceutical, and/or clinical research organizations. Please see the original reference for a full list of authors’ disclosures.


Sankaridurg P, Weng R, Tran H, et al. Spectacle lenses with highly aspherical lenslets for slowing myopia: a randomised, double-blind, cross-over clinical trial. Am J Ophthalmol. Published online November 5, 2022. doi:10.1016/j.ajo.2022.10.021