Researchers have identified 4 structural OCT features that may be associated with long-term best-corrected visual acuity (BCVA) outcomes in patients with Type 3 macular neovascularization (MNV), according to research published in Ophthalmology Retina. After 3 years of treatment with anti-vascular endothelial growth factor (anti-VEGF) injections, they found that baseline BCVA, the presence of subretinal fluid (SRF), the number of active lesions, and central macular thickness (CMT) were linked with long-term BCVA outcome. 

Investigators conducted a retrospective, longitudinal analysis of 40 eyes of 30 patients diagnosed with type 3 MNV (mean age 79±6 years, 21 pseudophakic, 21 women) who were treated with anti-VEGF injections (mean number of injections 10.1±4.7) and had a minimum follow-up of 3 years. They obtained baseline measurements of BCVA, mean CTM, subfoveal choroidal thickness (ChT), sublesion ChT, and mean ChT (0.34±0.28 logMAR, 408±138 µm, 176±81 µm, 177±84 µm, and 175±81 µm, respectively).

Overall, mean BCVA within the cohort decreased to 0.52±0.37 logMAR at 3 year follow-up (P =.002). Univariate analysis revealed that baseline BCVA, foveal involvement of exudation, and the presence of SRF (P =.004 for all) were associated with the 3 year BCVA outcome. Multivariate models showed independent associations between BCVA outcomes and baseline BCVA (ꞵ=0.335, P =.032), CMT (ꞵ=-0.383, P =.036), number of active T3 lesions (ꞵ=-0.284, P =.034), and presence of SRF (ꞵ=0.433, P =.008).

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“The analysis of possible predictors of anatomical and functional outcome is very useful in order to better customize the treatment of each patient,” according to the investigators. The study highlights their finding that “baseline BCVA and several structural OCT biomarkers (i.e. CMT, number of active lesions, and SRF) are associated with long-term BCVA outcome after 3-year treatment with anti-VEGF injections.”

Study limitations include a retrospective, single center design, small sample size, and ethnic homogeneity among participants.

Disclosure: Some study authors declared affiliations with biotech, pharmaceutical, and/or clinical research organizations. Please refer to the original article for a full list of disclosures.


Sacconi R, Forte P, Tombolini B, et al. Optical coherence tomography predictors of 3 year visual outcome for type 3 macular neovascularization. Ophthalmol Retina. Published online February 25, 2022. doi:10.1016/j.oret.2022.02.010