Exudative Age-Related Macular Degeneration Produces Higher Vitreomacular Traction Rates

Ophtalmology consultation
Ophtalmological practice, Geneva, Switzerland, Carrying out OCT angiography to detect the presence of neovascularisation, angiography with autofluorescence and optical coherence tomography. (Photo by: BSIP/Universal Images Group via Getty Images)
A team of investigators assess the natural course of vitreomacular traction in eyes with age-related macular degeneration and monitor spontaneous release rates.

Vitreomacular traction (VMT) prevalence is higher in eyes with exudative age-related macular degeneration (AMD) compared with eyes with nonexudative AMD, according to research published in Photodiagnosis and Photodynamic Therapy. However, researchers report that spontaneous release rates were comparable in eyes with idiopathic VMT.

Researchers retroscopically enrolled 46 patients (eyes, 55; mean age, 77±7.2 years; 25 men) with either exudative (eyes, 25) or nonexudative (eyes, 30) AMD and VMT in the study. Medical records were assessed for demographic data, intravitreal injection data, and instances of complete spontaneous release. The horizontal length of VMT (HLVMT), central macular thickness (CMT), and the horizontal length of choroidal neovascularization (HLCNV) were obtained using spectral-domain optical coherence tomography (SD-OCT). Follow-up was conducted between 6 to 24 months (mean follow-up time, 13.8±8 months).

Overall, spontaneous release occurred in 7 (28%) eyes with exudative AMD and 10 (33.3%) eyes with nonexudative AMD. On the final visit, HLVMT increased in 22 (40%) eyes and decreased in 8 (14.5%) eyes. The remaining 12 (21.8%) eyes exhibited unchanged HLVMT. In all eyes with choroidal neovascularization, the area of VMT corresponded with localization of the CNV complex. 

“Spontaneous release rates were found close to those with idiopathic VMT independently of the type of AMD, HLVMT, and IVI,” according to the researchers. “Considering the rate of spontaneous release rate, careful observation over time can be considered as an option in VMT management in eyes with AMD.”

Study limitations include the small sample size, lack of treat-naive eyes at the onset of the study, and failure to evaluate the 3-dimensional CNV area.


Garip R, Çınar AK, Çınar AC, Gürlü V. Prognostic factors Associated with the course of vitreomacular traction in eyes with age-related macular degeneration. Photodiagnosis Photodyn Ther. Published online July 20, 2022. doi:10.1016/j.pdpdt.2022.103025